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Sidec Technologies AB, Sweden, today announced a
contract research collaboration with The Cleveland Clinic Lerner
Research Institute, USA, to study a receptor protein involved in
human hypertension regulation.
Sidec’s method for 3-D analysis of real protein samples will be
utilized to characterize the atrial natriuretic peptide receptor (ANPR)
while interacting with its hormone ligand. The ANPR is a cell
membrane receptor protein and a critical component of a potent
anti-hypertension mechanism in humans. With insights to how the
receptor is activated by the hormone, researchers may be able to
design drugs that modulate receptor activity, and thus aid in the
treatment of hypertension.
“Hypertension is one of the leading causes of death throughout the
world. Using a 3-D protein analysis to determine how the system in
the body works to maintain optimal blood pressure may help in
developing medications to the mimic and enhance those regulatory
mechanisms,” said Kunio Misono, Ph.D., associate staff member in the
Department of Molecular Cardiology at the Lerner Research Institute
and the project’s principle investigator. The project is supported
by an NIH grant.
"We are happy to have established this important collaboration in
the USA. Our 3-D analysis technology will be used to assist
scientists at a well reputed research institute,” says Mr. Gösta
Sjöholm, Sidec’s Chief Executive Officer.
Sidec Technologies AB provides solutions for 3-D imaging of
biomolecules, based on the company’s patented technology. Sidec™
Electron Tomography (SET) enables visual characterization of
proteins in membranes or in solutions. By portraying the molecules
in a “frozen moment in time,” the company can, for example, extract
information about binding domains and the mechanisms of protein
interactions. Sidec is a privately held company originating from the
Karolinska Institute, and located in Stockholm, Sweden. Initially,
the company will focus on protein characterization at the drug
discovery and development market. SET is available on a contract
research basis delivering 3-D images and data of client samples.
Main investors are Karolinska Investment Fund and The Swedish
Industrial Development Fund. For more information, please visit
www.sidectech.com.
The Cleveland Clinic Foundation, founded in 1921, integrates
clinical and hospital care with research and education in a private,
not-for-profit, group practice. Approximately 1,100 full-time
salaried physicians at The Cleveland Clinic and Cleveland Clinic
Florida represent more than 100 medical specialties and
subspecialties. In 2001, there were more than 2.2 million outpatient
visits to The Cleveland Clinic. Patients came for treatment from
every state and from more than 80 countries. There were nearly
52,000 hospital admissions to The Cleveland Clinic in 2001. The
Cleveland Clinic website address is
www.clevelandclinic.org.
Statements in this press release that are not strictly historical
are "forward-looking" statements, which involve a high degree of
risk and uncertainty. Such statements are only predictions, and the
actual events or results may differ materially from those projected
in such forward-looking statements.
For press material, please visit our News & Events section at
www.sidectech.com
For further information, please contact:
Sidec Technologies AB
Gösta Sjöholm, CEO
Tel: +46 8 508 845 21
E-mail:
gosta.sjoholm@sidectech.se
Malin Engström, Marketing Director
Tel: +46 8 508 845 23
E-mail:
malin.engstrom@sidectech.se
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